GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7267979 | 1 | rs7020 | chr20:25278600 | ENTPD6 | chr20:25176339-25207360:+ | -0.3 | -6.73 | 4.98E-11 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs7020 | chr20:25278600 | FAM182B | chr20:25744102-25848786:- | 0.28 | 5.8 | 1.21E-8 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs7020 | chr20:25278600 | NINL | chr20:25433338-25566153:- | -0.35 | -7.16 | 2.97E-12 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs7020 | chr20:25278600 | PYGB | chr20:25228706-25278647:+ | -0.14 | -3.57 | 0.000386 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7849270 | 1 | rs7020708 | chr9:131885131 | CRAT | chr9:131857075-131873070:- | 0.29 | 6.95 | 1.19E-11 | Blood metabolite ratios |
| THCA | cis | rs965513 | 1 | rs7020976 | chr9:100547972 | C9orf156 | chr9:100666772-100684852:- | 0.13 | 3.6 | 0.000349 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | cis | rs7849270 | 1 | rs7021449 | chr9:131899312 | CRAT | chr9:131857075-131873070:- | 0.29 | 6.93 | 1.38E-11 | Blood metabolite ratios |
| THCA | cis | rs6477998 | 1 | rs7022397 | chr9:116007677 | CDC26 | chr9:116029290-116037869:- | -0.47 | -10.6 | 1.04E-23 | Hematology traits |
| THCA | cis | rs6477998 | 1 | rs7022397 | chr9:116007677 | PRPF4 | chr9:116037974-116055054:+ | 0.18 | 4.3 | 2.1E-5 | Hematology traits |
| THCA | cis | rs10760706 | 1 | rs7022999 | chr9:102694400 | STX17 | chr9:102668915-102736817:+ | -0.17 | -4.33 | 1.86E-5 | Alopecia areata |
| THCA | cis | rs7849270 | 1 | rs7023900 | chr9:131891152 | CRAT | chr9:131857075-131873070:- | 0.28 | 6.86 | 2.15E-11 | Blood metabolite ratios |
| THCA | cis | rs7870753 | 1 | rs7024214 | chr9:99239173 | CDC14B | chr9:99262397-99382112:- | -0.17 | -5.1 | 5.0E-7 | Height |
| THCA | cis | rs702485 | 1 | rs702485 | chr7:6449272 | DAGLB | chr7:6448748-6523849:- | -0.19 | -3.96 | 8.63E-5 | HDL cholesterol |
| THCA | cis | rs702485 | 1 | rs702485 | chr7:6449272 | RAC1 | chr7:6414126-6443597:+ | 0.16 | 3.66 | 0.000276 | HDL cholesterol |
| THCA | cis | rs965513 | 1 | rs7027030 | chr9:100550455 | C9orf156 | chr9:100666772-100684852:- | 0.13 | 3.64 | 0.000297 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |